Breadcrumb

Recent Publications

Batugedara, H., Li, J., Chen, G., Lu, D., Patel, J.J., Jang, J.C., Radecki, K.C., Burr, A.C., Lo, D.D., Dillman, A.R., and Nair, M.G., Hematopoietic cell-derived RELMα regulates hookworm immunity through effects on macrophages. J. Leukoc Biol,doi.org/10.1002/JLB.4A0917-369RR, 2018.

Peng, X., Madany, A.M., Jang, J.C., Valdez, J.M., Rivas, Z., Burr, A.C., Grinberg, Y.Y., Nordgren T.M., Nair, M.G., Cocker, D., Carson, M.J., and Lo, D., Continuous inhalation exposure to fungal allergen particulates induces lung inflammation while reducing basal expression of innate immune molecules in the brainstem. ASN Neuro, 10:1759091418782304, 2018.

Lo, D.D., Vigilance or subversion? Constitutive and inducible M cells in mucosal tissues. Trends Immunol39:185-195, 2018.

Parnell, E.A., Walch, E.M., Lo, D.D., Inducible colonic M cells are dependent on TNFR2 but not LTbR, identifying distinct signaling requirements for constitutive versus inducible M cells. J. Crohn’s and Colitis 11:751-760, 2017.

Gaieb, Z., Lo, D., Morikis, D., Molecular mechanism of biased ligand conformational changes in CC chemokine receptor 7. J. Chemical Information and Modeling 56:1808-22, 2016.

Bennett, K.M., Parnell, E.A., Sanscartier, C., Parks, S., Chen, G., Nair, M.G., and Lo, D.D., Induction of colonic M cells during intestinal inflammation. Am. J. Pathol. 186:1166-79, 2016.

Bennett, K.M., Gorham, R.D., Gusti, V., Trinh, L., Morikis, D., and Lo, D.D., Hybrid flagellin as a T cell independent vaccine scaffold. BMC Biotechnology, 15:71, 2015 (PMID 26265529).

Sakhon, O.S., Ross, B., Gusti, V., Pham, A.J., Vu, K., and Lo, D.D., M cell-derived vesicles suggest a unique pathway for trans-epithelial antigen delivery. Tissue Barriers 3:1-2 (e1004975), 2015.

Gusti, V., Bennett, K.M., and Lo, D.D., CD137 signaling enhances tight junction resistance in intestinal epithelial cells. Physiological Reports 2: e12090, 2014 (PMID 25096552).

Bennett, K.M., Walker, S.L., and Lo, D.D., Epithelial microvilli establish an electrostatic barrier to microbial adhesion. Infect. Immun. 82: 2860-2871, 2014. (PMID: 24778113) Highlighted in “IAI Spotlight”.

Sakhon, O.S., and Lo, D.D., Therapeutic implications of immune surveillance at the intestinal epithelial barrier. Curr. Drug Therapy 9:2-8, 2014.

Lo, D.D., Mucosal Vaccine Delivery: Is M cell targeted delivery effective in the mucosal lumen?. Expert Opinion on Drug Delivery, 10:157-61, 2013 (PMID:23252467).

Vandrangi, P., Lo, D.D., Kozaka, R., Ozaki, N., Carvajal, N., and Rodgers, V.G., Electrostatic properties of confluent Caco-2 cell layer correlates to their microvilli growth and determines underlying transcellular flow. Biotechnol. Bioeng. 110:2742-8, 2013.

Lo, D.D., Ling, J., Hamer, M.M., and Rajapaksa, T., Claudin-4 binding peptides, compositions and methods of use. U.S. Patent 8,258,257. Issued September 4, 2012.

Vandrangi, P., Jreij, P., Rajapaksa, T., Bansal, N., Lo, D., and Rodgers, V., Novel in-situ normal streaming potential device for characterizing electrostatic properties of confluent cells. Rev. Scientific Instruments, 83:074302, 2012. (PMID:22852705)

Hsieh, E.-H., and Lo, D.D., Jagged1 and Notch1 help edit M cell patterning in Peyer's patch follicle epithelium. Dev. Comp. Immunol. 37:306-12, 2012. (PMCID: PMC3374009)

Lo, D.D., Ling, J., and Eckelhoefer, H.A., M cell targeting by a claudin 4 targeting peptide can enhance mucosal IgA responses. BMC Biotechnology. 12:7, 2012. (PMCID:3337280)

Woodward, K., Bennett, K., and Lo, D.D., Mucosal vaccine design and delivery. Annu. Rev. Biomed. Engr. 14:17-46, 2012.

Wang, J., Gusti, V., Saraswati, A., and Lo, D. D., Convergent and divergent development among M cell lineages in mouse mucosal epithelium. J. Immunol. 187:5277-85, 2011. (PMCID: 3208058)

Lopez de Victoria, A., Gorham, R.D., Bellows, M.L., Ling, J., Lo, D.D., Floudas, C.A., and Morikis, D., A new generation of potent complement inhibitors of the Compstatin family. Chemical Biology and Drug Design, 77:431-40, 2011. (PMCID: PMC3095715)

Eckelhoefer, H.A., Rajapaksa, T.E., Wang, J., Stover-Hamer, M., Appleby, N.C., Ling, J., Lo, D.D., Claudin-4: Functional studies beyond the tight junction. Methods Mol. Biol. 762: 115-128, 2011. (PMID: 21717353)

Ploix, C.C., Noor, S., Crane, J., Masek, K., Carter, W., Lo, D.D., Wilson, E.H., and Carson, M.J., CNS-derived CCL21 is both sufficient to drive homeostatic T cell proliferation and necessary for efficient T cell migration into the CNS parenchyma following Toxoplasma gondii infection. Brain, Behavior, and Immunity 25:883-96, 2011. (PMCID: PMC3032828)

Rajapaksa, T.E., Bennett, K., Hamer, M , Lytle, C., Rodgers, V.G.J., and Lo, D.D., Intranasal M cell uptake of nanoparticles is independently influenced by targeting ligands and solvent ionic strength. J. Biol Chem. 285:23739-46, 2010. (PMCID: PMC2911333)

Hsieh, E.H., Fernandez, X., Wang, J., Stover-Hamer, M., Calvillo, S., Croft, M., Kwon, B.S., and Lo, D.D., CD137 is required for M cell functional maturation. Am. J. Pathol. 177: 666-676, 2010. (PMCID: PMC2913358)

Rajapaksa, T.E., Stover-Hamer, M., Fernandez, X., Eckelhoefer, H., and Lo, D.D., Claudin-4-targeted protein incorporated into PLGA nanoparticles can mediate M cell targeted delivery. J. Controlled Release 142: 196-205, 2010. (PMCID: PMC2823968)

Rajapaksa, T.E., and Lo, D.D., Microencapsulation of vaccine antigens and adjuvants for mucosal targeting. Current Immunology Reviews, 6:29-37, 2010.

Wang, J., Lopez-Fraga M., Rynko, A., Lo, D.D. TNFR and LTbetaR agonists induce Follicle-Associated Epithelium and M cell specific genes in rat and human intestinal epithelial cells. Cytokine 47:69-76, 2009. (PMCID: PMC2756805)

Ploix, C., Zuberi, R.I., Liu, F.-T., Carson, M.J., Lo, D.D. Induction and effector phase of allergic lung inflammation is independent of CCL21/CCL19 and LT-beta. Intl. J. Med. Sci. 6:85-92, 2009. (PMCID: PMC2653789)

Schmid, C., Melchior, B., Masek, K., Puntambekar, S., Danielson, P., Lo, D., Sutcliffe, J., and Carson, M., Differential gene expression in LPS/IFNg activated microglia and macrophages: in vitro versus in vivo. J. Neurochemistry 109:117-125, 2009. (PMCID: PMC2766614)

Clark, R.T., Hope, A., Lopez-Fraga, M., Schiller, N., and Lo, D.D., Bacterial particle endocytosis by epithelial cells is selective and enhanced by tumor necrosis factor-receptor ligands. Clin. Vacc. Immunol., 16:397-407, 2009. (PMCID: PMC2650861)

Ling, J., Liao, H., Clark, R., Wong, M.S.M., and Lo, D.D., Structural constraints for the binding of short peptides to Claudin-4 revealed by Surface Plasmon Resonance. J. Biol Chem., 283:30585-95, 2008. (PMCID: PMC2576538)

Li, C.R, Santoso, S., and Lo, D., Quantitative analysis of T cell homeostatic proliferation. Cell. Immunol., 250: 40-54, 2007. (PMCID: PMC2430158)

Carson, M.J., and Lo, D., Perspective is everything: an irreverent discussion of CNS-immune system interactions as viewed from different scientific traditions. Brain, Behavior, and Immunity, 21:367-73, 2006. (PMCID: PMC2626194)

Lo, D., Tynan, W., Dickerson, J., Scharf, M., Cooper, J., Byrne, D., Brayden, D., Higgins, L., Evans, C., and O'Mahony, D.J., Cell culture modeling of specialized tissue: Identification of genes expressed specifically by Follicle Associated Epithelium of Peyer's Patch by expression profiling of Caco-2/Raji co-cultures. Intl. Immunol. 16:91-99, 2004. (PMID: 14688064)

Lo, D., Tynan, W., Dickerson, J., Mendy, J., Chang, H.-W., Scharf, M., Byrne, D., Brayden, D., Higgins, L., Evans, C., O'Mahony, D.J., Peptidoglycan recognition protein expression in mouse Peyer's patch Follicle Associated Epithelium suggests functional specialization. Cell. Immunol. 224:8-16, 2003. (PMID: 14572796)